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Dr Sebastian Zeki

Gastroenterology consultant
Guy's and St Thomas' NHS Trust
ORCID · Google Scholar · GitHub · sebastianzeki.co.uk

Biography

Dr Sebastian Zeki is a consultant gastroenterologist at St Thomas' Hospital in London. His research interests include upper gastrointestinal physiology, upper gastrointestinal cancer, natural language programming and quality metrics in endoscopy. He co-leads the Gastroenterology data sciences Institute in London.

Research & Clinical Interests

Education & Qualifications

PhD - Genomics of Barrett's related malignancyUniversity of London, 2013
Member of the Royal College of Physician2006
MSc Health InformaticsCity University, 2003
MBBS MBChir MedicineUniversity College London, 2001
MA in experimental psychologyCambridge University, 1998

Experience

Honorary Senior Clinical Lecturer Oct 2019 – Present
King's College
Research and teaching in gastroenterology data sciences.
Co-head of the Gastroenterology Data Sciences Institute Jan 2017 – Present
Guy's & St Thomas' NHS Trust
Leading the Gastroenterology Data Sciences Institute.
Honorary Senior Clinical Lecturer Jan 2017 – Present
Bart's Cancer Institute
Consultant Gastroenterologist Apr 2015 – Present
Guy's & St Thomas' NHS Trust
NIHR Clinical Lecturer Jun 2013 – Apr 2015
Cambridge University: MRC Hutchison
PhD Student Jan 2010 – Jun 2013
Queen Mary University of London
Gastroenterology Registrar Jun 2006 – Jan 2016
North West Thames Training Rotation
Postgraduate Internal Medicine Training Jun 2001 – Jun 2006
London

Featured Publications

Precancerous niche remodelling dictates nascent tumour persistence.
G Skrupskelyte, JE Rojo Arias, H Ajith, Y Dang, D Rossetti, S Han et al.
Nature, 653(8113):242-253. 2026
Validating Impedance/pH Sensors for Measuring Oesophageal Transit: A Study Based on Dysphagia and Barium Swallow
Miah I, Wong T, Zeki S, Jafari J
Sensors, 25(11):3334. 2025
Artificial Intelligence Tools for the Diagnosis of Eosinophilic Esophagitis in Adults Reporting Dysphagia: Development, External Validation, and Software Creation for Point-of-Care Use
Visaggi P, Del Corso G, Baiano Svizzero F, Ghisa M, Bardelli S, Venturini A et al.
The Journal of Allergy and Clinical Immunology: In Practice, 12(4):1008-1016.e1. 2024
Automated decision making in Barrett’s oesophagus: development and deployment of a natural language processing tool
Zecevic A, Jackson L, Zhang X, Pavlidis P, Dunn J, Trudgill N et al.
npj Digital Medicine, 7(1). 2024
Clinical Characteristics, Endoscopic Findings, and Treatment Outcomes in Lymphocytic Esophagitis Compared to Eosinophilic Esophagitis
Visaggi P, Savarino E, Del Corso G, Herlihy N, Ghisa M, Dunn JM et al.
American Journal of Gastroenterology, 120(2):469-472. 2024
Ambulatory pH-Impedance Findings Confirm That Grade B Esophagitis Provides Objective Diagnosis of Gastroesophageal Reflux Disease
Visaggi P, Del Corso G, Gyawali CP, Ghisa M, Baiano Svizzero F, Stefani Donati D et al.
American Journal of Gastroenterology, 118(5):794-801. 2023

Grants & Funding

Can clinical decision making in Barrett's oesophagus surveillance be automated? A study using natural language processing gastrointestinal endoscopy reports Sep 2021 – Sep 2024
King's College London
Grant
Use of Machine Learning to automate decision making in Barrett's oesophagus surveillance Sep 2021 – Sep 2022
London and South East Postgraduate Medical and Dental Education
Award
Improving lesion recognition using routinely collected endoscopic and pathology data Oct 2019 – Feb 2021
Health Foundation
Grant
Clonal competition and genetic evolution of Barrett’s Oesophagus Aug 2010 – Aug 2013
British Society of Gastroenterology
Grant

Talks & Presentations

IBS for general practice- how to approach, how to help and how to treat Jun 2030
Natural language processing of endoscopic and pathological text Jun 2030

Educational Role

I contribute across the KCL–GSTT academic pathway: undergraduate, postgraduate, and faculty development.

Undergraduate (KCL MBBS).

  • Gastroenterology Small-Group Teaching Block (2016 to present),
  • Delivering teaching bedside and through lectures ~25 students annually.
  • Supervisor for scholarly project module 2025/6 Shan Lee “Is severe ineffective oesophageal motility at high resolution manometry related to gastro oesophageal reflux disease on impedance testing” Pierfrancesco Visaggi (June 2018 67(Suppl 1):A210.1-A210 DOI:10.1136/gutjnl-2018-BSGAbstracts.419 : “Oesophageal aperistalsis is under investigated in those without achalasia or reflux“ - oral presentation at British Society of Gastroenterology

Postgraduate:

  • Created innovative single subject per page online learning materials (www.gastroenteroloybook.com) with interactive multiple choice questions to improve Specialty Certificate Examination performance.
  • Publication of MRCP book (Zeki S. The Illustrated MRCP PACES Primer. Abingdon: Radcliffe Publishing; 2009. doi:10.1201/9780429091254) to help OSCE preparation for exams
  • Development of gastroenterology data science online teaching materials including full code examples to help manipulate large data sets using R (https://sebastiz.github.io/gastrodatascience//index.html)
  • Endoscopy trainer
  • Educational Supervisor Guy’s and St Thomas’ NHS Trust.

Supervision & mentoring.

  • Primary/secondary supervisor for 2 PhD candidates (topics: NLP for endoscopy):
  • One PhD completion to date: Zhang X. Automating Surveillance Timing for Barrett’s Oesophagus: An Information Extraction Approach Using Natural Language Processing [Doctoral thesis]. London: King’s College London; 2026.
  • Current primary PhD Supervisor for a second PhD : PhD supervision via the DRIVE Health programme (Agathe Zecevic “Development and deployment of a single unified natural language model for the supervised and automated prediction of follow up for precancerous GI conditions.”) (DRIVE- Health Programme)- Topol Digital Fellow

Educational innovation.

  • Designed an “Introduction to Clinical NLP for Gastroenterologists” workshop (hands-on notebooks using de-identified endoscopy text).
  • Website for NLP in gastroenterology

Training & standards.

  • JAG trainer and DOPS assessor;
  • Performance optimisation done with EndoMineR.
  • Contribution to Nocgca submission as national audit.
  • Development of automated adenoma detection rates for colonoscopy with demonstration (Regular feedback to individual endoscopists is associated with improved adenoma detection rate and other key performance indicators for colonoscopy.Lim S, Tritto G, Zeki S, DeMartino S.Frontline Gastroenterol. 2022 May 6;13(6):509-516. doi: 10.1136/flgastro-2022-102091. eCollection 2022)

All Publications

Endoscopy

Htet, Hein Myat Thu, Subramaniam, Sharmila, Parra-Blanco, Adolfo, Saunders, Brian, Suzuki, Noriko, Haji, Amyn, Hayee, Bu’Hussain, Ang, Yeng, di Pietro, Massimiliano, Iacucci, Marietta, others. Effectiveness and safety of a haemostatic gel in the treatment of intraprocedural bleeding and prevention of delayed bleeding after advanced endoscopic resection of large and complex gastrointestinal neoplasia: a multicentre prospective observational PuraStat study. Frontline Gastroenterology. 2026
Chevallay, Mickael, Barman, Sowrav, Moss, Charlotte, Van Hemelrijck, Mieke, Evans, Orla, Taylor, Joanna, Dunn, Jason, Baker, Cara, Kelly, Mark, Knight, William, others. Impact of endoscopic pyloric dilatation on symptom relief in delayed gastric emptying after esophageal resection—use of a novel symptom response questionnaire. Diseases of the Esophagus. 2025
Luber RP, Petri B, Meade S, Honap S, Zeki S, Gecse KB, Griffin N, Irving PM. Positioning intestinal ultrasound in a UK tertiary centre: Significant estimated clinical role and cost savings. Frontline Gastroenterology, 14(1):52-58. 2022 [link]
Lim S, Tritto G, Zeki S, DeMartino S. Regular feedback to individual endoscopists is associated with improved adenoma detection rate and other key performance indicators for colonoscopy. Frontline Gastroenterology, 13(6):509-516. 2022 [link]
Dunn JM, Reyhani A, Santaolalla A, Zylstra J, Gimson E, Pennington M, Baker C, Kelly M, Van Hemelrijck M, Lagergren J, Zeki SS, Gossage JA, Davies AR. Transition from esophagectomy to endoscopic therapy for early esophageal cancer. Diseases of the Esophagus, 35(3). 2022 [link]
Lim S, Haboubi HN, Anderson SHC, Dawson P, Machado AP, Mangsat E, Santos S, Wong T, Zeki S, Dunn J. Transnasal endoscopy: Moving from endoscopy to the clinical outpatient-blue sky thinking in oesophageal testing. Frontline Gastroenterology, 13(e1):e65-e71. 2022 [link]
Zeki S, Bergman J, Dunn J. Endoscopic management of dysplasia and early oesophageal cancer. Best Practice & Research Clinical Gastroenterology, 36-37:27-36. 2018 [link]
Sebastian Zeki. Experienced endoscopists improve Barrett's surveillance outcomes independently of time allocation Reply. ENDOSCOPY. 2017
Zeki SS. Squamous cell carcinoma after radiofrequency ablation for Barrett's dysplasia. World Journal of Gastroenterology, 20(15):4453. 2014 [link]

Natural Language Processing

Zhang, Xinyue, Zecevic, Agathe, Zeki, Sebastian, Roberts, Angus. ARGENT: Automatic Reference-free Evaluation for Open-Ended Text Generation without Source Inputs. Proceedings of the Fourth Workshop on Generation, Evaluation and Metrics (GEM$^2$). 2025
Zhang, Xinyue, Zecevic, Agathe, Zeki, Sebastian, Roberts, Angus. Improving Barrett’s Oesophagus Surveillance Scheduling with Large Language Models: A Structured Extraction Approach. Proceedings of the 24th Workshop on Biomedical Language Processing. 2025
Zecevic A, Jackson L, Zhang X, Pavlidis P, Dunn J, Trudgill N, Ahmed S, Visaggi P, YoonusNizar Z, Roberts A, Zeki SS. Automated decision making in Barrett’s oesophagus: development and deployment of a natural language processing tool. npj Digital Medicine, 7(1). 2024 [link]
Zecevic, A., Zhang, X., Zeki, S., Roberts, A.. Generation and Evaluation of Synthetic Endoscopy Free-Text Reports with Differential Privacy. BioNLP 2024 - 23rd Meeting of the ACL Special Interest Group on Biomedical Natural Language Processing, Proceedings of the Workshop and Shared Tasks.
Zhang, L.X., Roberts, A., Zeki, S.. Joint Entity and Relation Extraction in Medical Text. CEUR Workshop Proceedings. 2023
S Zeki S. EndoMineR for the extraction of endoscopic and associated pathology data from medical reports. Journal of Open Source Software, 3(24):701. 2018 [link]

Oesophageal Physiology

Miah I, Wong T, Zeki S, Jafari J. Validating Impedance/pH Sensors for Measuring Oesophageal Transit: A Study Based on Dysphagia and Barium Swallow. Sensors, 25(11):3334. 2025 [link]
Miah, Ismail, Wong, Terry, Zeki, Sebastian, Jafari, Jafar. Oesophageal Physiology Clinical Practice: A Case Study and Literature Review. Cureus. 2025
Miah, Ismail, Wong, Terry, Zeki, Sebastian, Jafari, Jafar. The Multichannel Intraoesophageal Impedance Transit Concept. Cureus. 2024
Rusu, Radu I, Fox, Mark R, Sweis, Rami, Zeki, Sebastian, Dunn, Jason M, Anggiansah, Angela, Jafari, Jafar, Learoyd, Annastazia, Wong, Terry. The optimal duration of pH monitoring: testing the validity of Lyon 2.0 recommendations for wireless pH measurement. Clinical Gastroenterology and Hepatology. 2024
Visaggi P, Del Corso G, Gyawali CP, Ghisa M, Baiano Svizzero F, Stefani Donati D, Venturini A, Savarino V, Penagini R, Zeki S, Bellini M, Savarino EV, de Bortoli N. Ambulatory pH-Impedance Findings Confirm That Grade B Esophagitis Provides Objective Diagnosis of Gastroesophageal Reflux Disease. American Journal of Gastroenterology, 118(5):794-801. 2023 [link]
Zeki SS, Miah I, Visaggi P, Wolak A, deSilva M, Dunn JM, Davies A, Gossage J, Botha A, Sui G, Jafari J, Wong T. Extended Wireless pH Monitoring Significantly Increases Gastroesophageal Reflux Disease Diagnoses in Patients With a Normal pH Impedance Study. Journal of Neurogastroenterology and Motility, 29(3):335-342. 2023 [link]
O'Toole S, Moazzez R, Wojewodka G, Zeki S, Jafari J, Hope K, Brand A, Hoare Z, Scott S, Doungsong K, Ezeofor V, Edwards RT, Drakatos P, Steier J. Single-centre, single-blinded, randomised, parallel group, feasibility study protocol investigating if mandibular advancement device treatment for obstructive sleep apnoea can reduce nocturnal gastro-oesophageal reflux (MAD-Reflux trial). BMJ Open, 13(8):e076661. 2023 [link]
Rusu R, Fox MR, Tucker E, Zeki S, Dunn JM, Jafari J, Warburton F, Wong T. Validation of the Lyon classification for GORD diagnosis: Acid exposure time assessed by prolonged wireless pH monitoring in healthy controls and patients with erosive oesophagitis. Gut, 70(12):2230-2237. 2021 [link]

Cancer Basic Science

G Skrupskelyte, JE Rojo Arias, H Ajith, Y Dang, D Rossetti, S Han, MKS Tang, MT Bejar, B Colom, JC Fowler, K Murai, W Knight, D Aust, MHH Schmidt, J Jászai, S Zeki, A Noorani, PH Jones, S Rulands, BD Simons, MP Alcolea. Precancerous niche remodelling dictates nascent tumour persistence.. Nature, 653(8113):242-253. 2026 [link]
Abujudeh S, Zeki SS, van Lanschot MC, Pusung M, Weaver JM, Li X, Noorani A, Metz AJ, Bornschein J, Bower L, Miremadi A, Fitzgerald RC, Morrissey ER, Lynch AG. Low-cost and clinically applicable copy number profiling using repeat DNA. BMC Genomics, 23(1). 2022 [link]
Duits LC, Lao-Sirieix P, Wolf WA, O’Donovan M, Galeano-Dalmau N, Meijer SL, Offerhaus GJA, Redman J, Crawte J, Zeki S, Pouw RE, Chak A, Shaheen NJ, Bergman JJGHM, Fitzgerald RC. A biomarker panel predicts progression of Barrett's esophagus to esophageal adenocarcinoma. Diseases of the Esophagus, 32(1). 2019 [link]
Sebastian Zeki. Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction. International journal of cancer. 2019
Noorani A, Goddard M, Crawte J, Alexandrov LB, Secrier M, Eldridge MD, Bower L, Li X, Weaver J, LaooSirieix P, Martincorena I, DebirammBeecham I, Grehan N, MacRae S, Malhotra S, Miremadi A, Thomas T, Galbraith S, Petersen L, Preston SD, Gilligan D, Hindmarsh A, Hardwick RH, Consortium O, Stratton MR, Wedge DC, Fitzgerald RC. Clonal Diaspora in Metastatic Esophageal Adenocarcinoma Describes a New Model of Cancer Progression. SSRN Electronic Journal. 2018 [link]
Sebastian Zeki. A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre-and post-chemotherapy. Genome research. 2017
Pusung M, Zeki S, Fitzgerald R. Genomics of esophageal cancer and biomarkers for early detection. Advances in Experimental Medicine and Biology. 2016 [link]
Zeki S, Fitzgerald RC. The use of molecular markers in predicting dysplasia and guiding treatment. Best Practice & Research Clinical Gastroenterology, 29(1):113-124. 2015 [link]
Weaver JMJ, Ross-Innes CS, Shannon N, Lynch AG, Forshew T, Barbera M, Murtaza M, Ong CJ, Lao-Sirieix P, Dunning MJ, Smith L, Smith ML, Anderson CL, Carvalho B, O'Donovan M, Underwood TJ, May AP, Grehan N, Hardwick R, Davies J, Oloumi A, Aparicio S, Caldas C, Eldridge MD, Edwards PAW, Rosenfeld N, Tavaré S, Fitzgerald RC. Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis. Nature Genetics, 46(8):837-843. 2014 [link]
Lavery DL, Nicholson AM, Poulsom R, Jeffery R, Hussain A, Gay LJ, Jankowski JA, Zeki SS, Barr H, Harrison R, Going J, Kadirkamanathan S, Davis P, Underwood T, Novelli MR, Rodriguez–Justo M, Shepherd N, Jansen M, Wright NA, McDonald SAC. The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands. Gut, 63(12):1854-1863. 2014 [link]
Sebastian Zeki. Clonal Interactions in Barrett�s Carcinogenesis.. . 2013
Zeki SS, Haidry R, Graham TA, Rodriguez-Justo M, Novelli M, Hoare J, Dunn J, Wright NA, Lovat LB, McDonald SA. Clonal selection and persistence in dysplastic Barrett's esophagus and intramucosal cancers after failed radiofrequency ablation. American Journal of Gastroenterology, 108(10):1584-1592. 2013 [link]
Khan S, McDonald SA, Wright NA, Graham TA, Odze RD, Rodriguez‐Justo M, Zeki S. Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells. The Journal of Pathology, 231(1):98-104. 2013 [link]
Zeki S, Graham TA, McDonald SAC. Utilizing DNA mutations to trace epithelial cell lineages in human tissues. Methods in Molecular Biology. 2012 [link]
Zeki, S.S., McDonald, S.A., Graham, T.A.. Field cancerization in Barrett's esophagus.. Discovery medicine. 2011
Zeki SS, Graham TA, Wright NA. Stem cells and their implications for colorectal cancer. Nature Reviews Gastroenterology & Hepatology, 8(2):90-100. 2011 [link]

Eosinophilic Oesophagitis

Visaggi P, Del Corso G, Baiano Svizzero F, Ghisa M, Bardelli S, Venturini A, Stefani Donati D, Barberio B, Marciano E, Bellini M, Dunn J, Wong T, de Bortoli N, Savarino EV, Zeki S. Artificial Intelligence Tools for the Diagnosis of Eosinophilic Esophagitis in Adults Reporting Dysphagia: Development, External Validation, and Software Creation for Point-of-Care Use. The Journal of Allergy and Clinical Immunology: In Practice, 12(4):1008-1016.e1. 2024 [link]
Visaggi P, Savarino E, Del Corso G, Herlihy N, Ghisa M, Dunn JM, Marciano E, Wong T, Green M, de Bortoli N, Zeki S. Clinical Characteristics, Endoscopic Findings, and Treatment Outcomes in Lymphocytic Esophagitis Compared to Eosinophilic Esophagitis. American Journal of Gastroenterology, 120(2):469-472. 2024 [link]
Visaggi P, Savarino E, Del Corso G, Hunter H, Baiano Svizzero F, Till SJ, Dunn J, Wong T, de Bortoli N, Zeki S. Six-Food Elimination Diet Is Less Effective During Pollen Season in Adults With Eosinophilic Esophagitis Sensitized to Pollens. American Journal of Gastroenterology, 118(11):1957-1962. 2023 [link]
Hunter H, Pupinyte K, Wong T, Zeki S, Dunn JM, Toner E, Till SJ, Lomer MCE. Multidisciplinary approach to the management of adult eosinophilic oesophagitis in the United Kingdom. Clinical & Experimental Allergy, 48(12):1752-1756. 2018 [link]

Cancer Clinical

Chevallay, Mickael, Barman, Sowrav, Moss, Charlotte, Van Hemelrijck, Mieke, Evans, Orla, Taylor, Joanna, Dunn, Jason, Baker, Cara, Kelly, Mark, Knight, William, others. Development of a symptom response to treatment questionnaire for patients in follow-up after oesophago-gastrectomy for cancer. Diseases of the Esophagus. 2025
Bott, R, Zylstra, J, Knight, W, Whyte, GP, Lane, AM, Moss, C, Browning, M, Lagergren, J, Van Hemelrijck, M, Davies, AR, others. Prehabilitation of Patients With Oesophageal Malignancy Undergoing Peri-Operative Treatment (Pre-EMPT): Outcomes From a Prospective Controlled Trial. Journal of Surgical Oncology. 2025
Byrne, Ben E, Siaw-Acheampong, Kwabena, Evans, Orla, Taylor, Joanna, Huddy, Fiona, Nilsson, Magnus, Griffiths, Ewen A, Low, Donald, Gossage, James, Dunn, Jason, others. REsolution of Symptoms afTer Oesophago-gastric cancer REsection delphi (RESTOREd)—standardizing the definition, investigation and management of gastrointestinal symptoms and conditions after surgery. British Journal of Surgery. 2024
Withey SJ, Owczarczyk K, Grzeda MT, Yip C, Deere H, Green M, Maisey N, Davies AR, Cook GJ, Goh V, Baker C, Bell J, Chang F, Chicklore S, Cominos M, Coombes A, Dunn J, George S, Gill-Barman B, Gossage J, Gourtsoyianni S, Green A, Griffin N, Hill M, Hynes O, Iezzi C, Jacques A, Kelly M, Mahadeva U, McEwan R, Meenan J, Neji R, Ngan S, Padormo F, Qureshi A, Reyhani A, Sharkey A, Spence J, Subesinghe M, Tham G, Waters J, Zeki S. Association of dynamic contrast-enhanced MRI and <sup>18</sup>F-Fluorodeoxyglucose PET/CT parameters with neoadjuvant therapy response and survival in esophagogastric cancer. European Journal of Surgical Oncology, 49(10):106934. 2023 [link]
Moore JL, Subesinghe M, Santaolalla A, Green M, Deere H, Van Hemelrijck M, Lagergren J, Chicklore S, Maisey N, Gossage JA, Kelly M, Baker CR, Davies AR, Jacques A, Griffin N, Goh V, Ngan S, Owczarczyk K, Sita-Lumsden A, Qureshi A, Chang F, Mahadeva U, Gill-Barman B, George S, Ong M, Waters J, Cominos M, Sevitt T, Hynes O, Tham G, Dunn JM, Zeki SS. Metabolic tumour and nodal response to neoadjuvant chemotherapy on FDG PET-CT as a predictor of pathological response and survival in patients with oesophageal adenocarcinoma. European Radiology, 33(5):3647-3659. 2023 [link]
Reyhani A, Gimson E, Baker C, Kelly M, Maisey N, Meenan J, Subesinghe M, Hill M, Lagergren J, Gossage J, Zeki S, Dunn J, Davies A. Multiple staging investigations may not change management in patients with high-grade dysplasia or early esophageal adenocarcinoma. Diseases of the Esophagus, 36(10). 2023 [link]
Moore JL, Green M, Santaolalla A, Deere H, Evans RP, Elshafie M, Lavery A, McManus DT, McGuigan A, Douglas R, Horne J, Walker R, Mir H, Terlizzo M, Kamarajah SK, Van Hemelrijck M, Maisey N, Sita-Lumsden A, Ngan S, Kelly M, Baker CR, Kumar S, Lagergren J, Allum WH, Gossage JA, Griffiths EA, Grabsch HI, Turkington RC, Underwood TJ, Smyth EC, Fitzgerald RC, Cunningham D, Davies AR, Puig S, Chaudry A, Jacques A, Griffin N, Goh V, Owczarczyk K, Qureshi A, Subesinghe M, Chang F, Mahadeva U, Gill-Barman B, George S, Ong M, Waters J, Cominos M, Sevitt T, Hill M, Hynes O, Tham G, Knight WRC, Dunn JM, Zeki SS. Pathologic Lymph Node Regression After Neoadjuvant Chemotherapy Predicts Recurrence and Survival in Esophageal Adenocarcinoma: A Multicenter Study in the United Kingdom. Journal of Clinical Oncology, 41(28):4522-4534. 2023 [link]
Moore JL, Davies AR, Santaolalla A, Van Hemelrijck M, Maisey N, Lagergren J, Gossage JA, Kelly M, Baker CR, Jacques A, Griffin N, Goh V, Ngan S, Lumsden A, Owczarczyk K, Qureshi A, Deere H, Green M, Chang F, Mahadeva U, Gill-Barman B, George S, Meenan J, Hill M, Waters J, Cominos M, Hynes O, Tham G, Bott RK, Dunn JM, Zeki SS. Clinical Relevance of the Tumor Location-Modified Laurén Classification System for Gastric Cancer in a Western Population. Annals of Surgical Oncology, 29(6):3911-3920. 2022 [link]
Moore JL, Kumar S, Santaolalla A, Patel PH, Kapiris M, Van Hemelrijck M, Maisey N, Hill M, Lagergren J, Gossage JA, Kelly M, Chaudry A, Allum WH, Baker CR, Cunningham D, Davies AR, Jacques A, Griffin N, Goh V, Ngan S, Owczarczyk K, Lumsden A, Qureshi A, Deere H, Green M, Chang F, Mahadeva U, Gill-Barman B, George S, Ong M, Waters J, Cominos M, Sevitt T, Hynes O, Tham G, Bott R, Dunn J, Zeki S. Effect of peri-operative chemotherapy regimen on survival in the treatment of locally advanced oesophago-gastric adenocarcinoma – A comparison of the FLOT and ‘MAGIC’ regimens. European Journal of Cancer, 163:180-188. 2022 [link]
Pucher PH, Coombes A, Evans O, Taylor J, Moore JL, White A, Lagergren J, Baker C, Kelly M, Gossage JA, Dunn J, Zeki S, Byrne BE, Andreyev J, Davies AR. Patient perspectives on key symptoms and preferences for follow-up after upper gastro-intestinal cancer surgery. Supportive Care in Cancer, 30(6):5269-5275. 2022 [link]
Knight WRC, Baker CR, Griffin N, Wulaningsih W, Kelly M, Davies AR, Gossage JA, Hynes O, Tham G, Iezzi C, Bott R, Maisey N, Gaya A, Ngan S, Qureshi A, Green M, Jacques A, Goh V, Deere H, Chang F, Mahadeva U, Gill-Barman B, George S, Dunn J, Zeki S, Meenan J. Does a high Mandard score really define a poor response to chemotherapy in oesophageal adenocarcinoma?. British Journal of Cancer, 124(10):1653-1660. 2021 [link]
Sharkey AR, Sah B, Withey SJ, Bhuva S, Neji R, Jeljeli S, Green A, Cook GJR, Goh V, Baker CR, Chang F, Chicklore S, Cominos M, Coombes A, Davies AR, George S, Gill-Barman B, Dunn JN, Gossage JA, Griffin N, Hill M, Hynes O, Iezzi C, Jacques A, Kelly M, Mahadeva U, Maisey N, McEwan R, Meenan J, Ngan S, Owczarczyk K, Qureshi A, Reyhani A, Subesinghe M, Tham G, Waters J, Zeki SS. Initial experience in staging primary oesophageal/gastro-oesophageal cancer with 18F-FDG PET/MRI. European Journal of Hybrid Imaging, 5(1). 2021 [link]
Bott, R.K., Beckmann, K., Zylstra, J., Wilkinson, M.J., Knight, W.R.C., Baker, C.R., Kelly, M., Maisey, N., Qureshi, A., Sevitt, T., Van Hemelrijck, M., Smyth, E.C., Allum, W.H., Lagergren, J., Gossage, J.A., Cunningham, D., Davies, A.R., McEwan, R., Jacques, A., Griffin, N., Goh, V., Ngan, S., Owczarczyk, K., Deere, H., Green, M., Chang, F., Mahadeva, U., Gill-Barman, B., George, S., Meenan, J., Hill, M., Waters, J., Cominos, M., Hynes, O., Coombes, A., Tham, G., Iezzi, C., Reyhani, A., Dunn, J.M., Zeki, S.S.. Adjuvant therapy following oesophagectomy for adenocarcinoma in patients with a positive resection margin. Surgical Oncology Clinics of North America, 13(4):555-566. 2020 [link]
Rahman SA, Walker RC, Lloyd MA, Grace BL, van Boxel GI, Kingma BF, Ruurda JP, van Hillegersberg R, Harris S, Parsons S, Mercer S, Griffiths EA, O'Neill JR, Turkington R, Fitzgerald RC, Underwood TJ, Noorani A, Elliott RF, Edwards PAW, Grehan N, Nutzinger B, Crawte J, Chettouh H, Contino G, Li X, Gregson E, Zeki S, de la Rue R, Malhotra S, Tavaré S, Lynch AG, Smith ML, Davies J, Crichton C, Carroll N, Safranek P, Hindmarsh A, Sujendran V, Hayes SJ, Ang Y, Preston SR, Oakes S, Bagwan I, Save V, Skipworth RJE, Hupp TR, O'Neill JR, Tucker O, Beggs A, Taniere P, Puig S, Underwood TJ, Noble F, Byrne JP, Kelly JJ, Owsley J, Barr H, Shepherd N, Old O, Lagergren J, Gossage J, Chang ADF, Zylstra J, Goh V, Ciccarelli FD, Sanders G, Berrisford R, Harden C, Bunting D, Lewis M, Cheong E, Kumar B, Parsons SL, Soomro I, Kaye P, Saunders J, Lovat L, Haidry R, Eneh V, Igali L, Scott M, Sothi S, Suortamo S, Lishman S, Hanna GB, Peters CJ, Grabowska A. Machine learning to predict early recurrence after oesophageal cancer surgery. British Journal of Surgery, 107(8):1042-1052. 2020 [link]
Knight WRC, Yip C, Wulaningsih W, Jacques A, Griffin N, Zylstra J, Van Hemelrijck M, Maisey N, Gaya A, Baker CR, Kelly M, Gossage JA, Lagergren J, Landau D, Goh V, Davies AR, Ngan S, Qureshi A, Deere H, Green M, Chang F, Mahadeva U, Gill‐Barman B, George S, Dunn J, Zeki S, Meenan J, Hynes O, Tham G, Iezzi C. Prediction of a positive circumferential resection margin at surgery following neoadjuvant chemotherapy for adenocarcinoma of the oesophagus. BJS Open, 3(6):767-776. 2019 [link]
Davies AR, Myoteri D, Zylstra J, Baker CR, Wulaningsih W, Van Hemelrijck M, Maisey N, Allum WH, Smyth E, Gossage JA, Lagergren J, Cunningham D, Green M, Kelly M, Ngan S, Qureshi A, Gaya A, Griffin N, Jacques A, Goh V, Deere H, Chang F, Mahadeva U, Gill-Barman B, George S, Dunn J, Zeki S, Meenan J, Hynes O, Tham G, Iezzi C, Dellaportas D, Cowie A, Knight W, Valeri N. Lymph node regression and survival following neoadjuvant chemotherapy in oesophageal adenocarcinoma. British Journal of Surgery, 105(12):1639-1649. 2018 [link]

Inflammatory Bowel Disease

Meade S, Routledge E, Sharma E, Honap S, Zeki S, Ray S, Anderson SHC, Sanderson J, Mawdsley J, Irving PM, Samaan MA. How achievable are STRIDE-II treatment targets in real-world practice and do they predict long-term treatment outcomes?. Frontline Gastroenterology, 14(4):312-318. 2023 [link]
Meade S, Patel KV, Luber RP, O'Hanlon D, Caracostea A, Pavlidis P, Honap S, Anandarajah C, Griffin N, Zeki S, Ray S, Mawdsley J, Samaan MA, Anderson SH, Darakhshan A, Adams K, Williams A, Sanderson JD, Lomer M, Irving PM. A retrospective cohort study: pre-operative oral enteral nutritional optimisation for Crohnʼs disease in a UK tertiary IBD centre. Alimentary Pharmacology &amp; Therapeutics, 56(4):646-663. 2022 [link]
Sebastian Zeki. The effects of COVID-19 on IBD prescribing and service provision in a UK tertiary centre. GastroHep. 2020
Zeki S, Catnach S, King A, Hallan R. An obstructing mass in a young ulcerative colitis patient. World Journal of Gastroenterology, 15(7):877. 2009 [link]
Williams HRT, Cox IJ, Walker DG, North BV, Patel VM, Marshall SE, Jewell DP, Ghosh S, Thomas HJW, Teare JP, Jakobovits S, Zeki S, Welsh KI, Taylor-Robinson SD, Orchard TR. Characterization of inflammatory bowel disease with urinary metabolic profiling. The American Journal of Gastroenterology, 104(6):1435-1444. 2009 [link]

Other

Zeki S. The Illustrated MRCP PACES Primer. . 2022 [link]
Digby-Bell J, Zeki S. Uvular necrosis following diagnostic gastroscopy. BMJ Case Reports, 2017:bcr-2017-221959. [link]
Zeki S, Fitzgerald RC. Targeting care in Barrett's oesophagus. Clinical Medicine, 14(6):s78-s83. 2014 [link]
Zeki S, Culkin A, Gabe SM, Nightingale JM. Refeeding hypophosphataemia is more common in enteral than parenteral feeding in adult in patients. Clinical Nutrition, 30(3):365-368. 2011 [link]
Sebastian Zeki. A deceptive magnetic resonance cholangiopancreatogram?. Grand Rounds. 2010
Phillips A, Bassett P, Zeki S, Newman S, Pasvol G. Risk factors for severe disease in adults with falciparum malaria. Clinical Infectious Diseases, 48(7):871-878. 2009 [link]
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