Dr Sebastian Zeki

Dr Sebastian Zeki

Gastroenterology consultant

Guy's and St Thomas' NHS Trust

Biography

Dr Sebastian Zeki is a consultant gastroenterologist at St Thomas’ Hospital in London. His research interests include upper gastrointestinal physiology, upper gastrointestinal cancer, natural language programming and quality metrics in endoscopy. He co-leads the Gastroenterology data sciences Institute in London.

Interests

  • Endoscopic therapy
  • Oesophageal and stomach cancers/Barrett’s oesophagus
  • Oesophageal physiology
  • Heartburn; chest pain; indigestion; bloating; spasm; dyspepsia; irritable bowel syndrome; swallowing disorders; hoarse voice; chronic cough and throat clearing
  • Eosinophilic oesophagitis
  • High quality endoscopy
  • Machine learning/R/Natural language programming
  • Genomics

Education

  • PhD - Genomics of Barrett's related malignancy, 2013

    University of London

  • Member of the Royal College of Physician, 2006

  • MSc Health Informatics, 2003

    City University

  • MBBS MBChir Medicine, 2001

    University College London

  • MA in experimental psychology, 1998

    Cambridge University

Experience

 
 
 
 
 

Honorary Senior Clinical Lecturer

King’s College

Oct 2019 – Present London
Research and teaching in gastroenterology data sciences.
 
 
 
 
 

Co-head of the Gastroenterology Data Sciences Institute

Guy’s & St Thomas’ NHS Trust

Jan 2017 – Present London
Leading the Gastroenterology Data Sciences Institute.
 
 
 
 
 

Honorary Senior Clinical Lecturer

Bart’s Cancer Institute

Jan 2017 – Present London
 
 
 
 
 

Consultant Gastroenterologist

Guy’s & St Thomas’ NHS Trust

Apr 2015 – Present London
 
 
 
 
 

NIHR Clinical Lecturer

Cambridge University: MRC Hutchison

Jun 2013 – Apr 2015 London
 
 
 
 
 

PhD Student

Queen Mary University of London

Jan 2010 – Jun 2013 London
 
 
 
 
 

Gastroenterology Registrar

North West Thames Training Rotation

Jun 2006 – Jan 2016 London
 
 
 
 
 

Postgraduate Internal Medicine Training

London

Jun 2001 – Jun 2006 London

Funding

Research grants and awards

Can clinical decision making in Barrett’s oesophagus surveillance be automated? A study using natural language processing gastrointestinal endoscopy reports

Grant

Use of Machine Learning to automate decision making in Barrett’s oesophagus surveillance

Award

Improving lesion recognition using routinely collected endoscopic and pathology data

Grant

Clonal competition and genetic evolution of Barrett’s Oesophagus

Grant

Talks

IBS for General Practice — How to Approach, Help and Treat

Webinar covering evidence-based guidance for IBS diagnosis and treatment, with approaches for empowering patients.

  • Invited speaker, Royal College Physicians “Artificial intelligence in gastroenterology Vision 2020” Royal College of Physician.
  • Invited speaker, King’s Health Partners Academic Surgical Grand Round / ALRSG-BI webinar. “Intelligent physiology: a roadmap to using concurrent physiology as a surgical guide.” 25 March 2021.
  • Invited faculty/chair, London International Upper GI Symposium. Chair, Oesophageal Disorders session. 26 February 2021.
  • Invited speaker, AImed. “Automation in endoscopy.” Jan 3, 2021.
  • Invited speaker- “How to develop an Endoscopic submucosal dissection service” 2023- St Thomas’ Upper GI Day.
  • Invited speaker, Dr Falk educational meeting. Managing Complications – Eosinophilic oesophagitis Royal College of Physicians in London on Friday 22nd March 2024.
  • Invited keynote speaker, British Society of Gastroenterology Annual Meeting / BSG LIVE’25. “What is the role of Natural Language Processing in Gastroenterology?.” SEC Glasgow, 23–26 June 2025.
  • Invited speaker, British Voice Association Voice Clinics Forum. Topic: laryngopharyngeal reflux / persistent throat symptoms. Guy’s Hospital, London. 6 February 2026. “Reflux and the voice- an evidence based approach”

Software

EndoMineR

An R package for extracting structured data from free-text endoscopy and pathology reports, linking pathology to procedures and tracking Barrett’s surveillance timelines. View on GitHub

Gastrodatascience

An educational resource for gastroenterology data science, covering R, machine learning, and NLP applied to clinical data. Visit site

Gastroenterology Teaching Book

A free online resource for gastroenterology teaching aimed at medical students and junior doctors. Visit site

Health Foundation Grant — Improving Lesion Recognition

Using routinely collected endoscopic and pathology data to improve lesion recognition quality metrics across endoscopy units.

MiFlo

Research project exploring minimally invasive flow measurements in gastrointestinal physiology.

Physipop

Package to automate extraction of oesophageal physiology metrics https://github.com/sebastiz/Physipopv2.0.3

PhysiMiner & PhysiMinerpy

Libraries written in R and python to automate analysis of oesophageal physiology results (ph impedance, high resolution manometry and wireless pH capsules) (https://github.com/sebastiz/PhysiMineRpy & https://github.com/sebastiz/PhysiMineR)

pyEPIC & STH analytics

Python libraries for simplifying access to EPIC Clarity data and legacy data in the Enterprise Data Warehouse (EDW). (https://github.com/AgatheZ/pyEPIC & https://github.com/sebastiz/pySTH_Analytics)

EndoMiner

Zeki SS. EndoMineR for the extraction of endoscopic and associated pathology data from medical reports. Journal of Open Source Software. 2018;3(24):701. doi:10.21105/joss.00701.

Educational Role

I contribute across the KCL–GSTT academic pathway: undergraduate, postgraduate, and faculty development.

Undergraduate (KCL MBBS).

  • Gastroenterology Small-Group Teaching Block (2016 to present),
  • Delivering teaching bedside and through lectures ~25 students annually.
  • Supervisor for scholarly project module 2025/6 Shan Lee “Is severe ineffective oesophageal motility at high resolution manometry related to gastro oesophageal reflux disease on impedance testing” Pierfrancesco Visaggi (June 2018 67(Suppl 1):A210.1-A210 DOI:10.1136/gutjnl-2018-BSGAbstracts.419 : “Oesophageal aperistalsis is under investigated in those without achalasia or reflux“ - oral presentation at British Society of Gastroenterology

Postgraduate:

  • Created innovative single subject per page online learning materials (www.gastroenteroloybook.com) with interactive multiple choice questions to improve Specialty Certificate Examination performance.
  • Publication of MRCP book (Zeki S. The Illustrated MRCP PACES Primer. Abingdon: Radcliffe Publishing; 2009. doi:10.1201/9780429091254) to help OSCE preparation for exams
  • Development of gastroenterology data science online teaching materials including full code examples to help manipulate large data sets using R (https://sebastiz.github.io/gastrodatascience//index.html)
  • Endoscopy trainer
  • Educational Supervisor Guy’s and St Thomas’ NHS Trust.

Supervision & mentoring.

  • Primary/secondary supervisor for 2 PhD candidates (topics: NLP for endoscopy):
  • One PhD completion to date: Zhang X. Automating Surveillance Timing for Barrett’s Oesophagus: An Information Extraction Approach Using Natural Language Processing [Doctoral thesis]. London: King’s College London; 2026.
  • Current primary PhD Supervisor for a second PhD : PhD supervision via the DRIVE Health programme (Agathe Zecevic “Development and deployment of a single unified natural language model for the supervised and automated prediction of follow up for precancerous GI conditions.”) (DRIVE- Health Programme)- Topol Digital Fellow

Educational innovation.

  • Designed an “Introduction to Clinical NLP for Gastroenterologists” workshop (hands-on notebooks using de-identified endoscopy text) now adopted by deanery study days; satisfaction 4./5.
  • Website for NLP in gastroenterology

Training & standards.

  • JAG trainer and DOPS assessor;
  • Performance optimisation done with EndoMineR.
  • Contribution to Nocgca submission as national audit.
  • Development of automated adenoma detection rates for colonoscopy with demonstration (Regular feedback to individual endoscopists is associated with improved adenoma detection rate and other key performance indicators for colonoscopy.Lim S, Tritto G, Zeki S, DeMartino S.Frontline Gastroenterol. 2022 May 6;13(6):509-516. doi: 10.1136/flgastro-2022-102091. eCollection 2022)

Endoscopy Videos

Videos of endoscopic procedures and techniques from my YouTube channel.

▶ Watch on YouTube
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All Publications

Endoscopy

Effectiveness and safety of a haemostatic gel in the treatment of intraprocedural bleeding and prevention of delayed bleeding after advanced endoscopic resection of large and complex gastrointestinal neoplasia: a multicentre prospective observational PuraStat study

Impact of endoscopic pyloric dilatation on symptom relief in delayed gastric emptying after esophageal resection—use of a novel symptom response questionnaire

Transition from esophagectomy to endoscopic therapy for early esophageal cancer

Transnasal endoscopy: Moving from endoscopy to the clinical outpatient-blue sky thinking in oesophageal testing

Oesophageal Physiology

Oesophageal Physiology Clinical Practice: A Case Study and Literature Review

The Multichannel Intraoesophageal Impedance Transit Concept

The optimal duration of pH monitoring: testing the validity of Lyon 2.0 recommendations for wireless pH measurement

Ambulatory pH-Impedance Findings Confirm That Grade B Esophagitis Provides Objective Diagnosis of Gastroesophageal Reflux Disease

Extended Wireless pH Monitoring Significantly Increases Gastroesophageal Reflux Disease Diagnoses in Patients With a Normal pH Impedance Study

Cancer Basic Science

Precancerous niche remodelling dictates nascent tumour persistence.

Low-cost and clinically applicable copy number profiling using repeat DNA

A biomarker panel predicts progression of Barrett's esophagus to esophageal adenocarcinoma

Clonal Diaspora in Metastatic Esophageal Adenocarcinoma Describes a New Model of Cancer Progression

The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands

Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis

Clonal selection and persistence in dysplastic Barrett's esophagus and intramucosal cancers after failed radiofrequency ablation

Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells

Field cancerization in Barrett's esophagus.

Eosinophilic Oesophagitis

Artificial Intelligence Tools for the Diagnosis of Eosinophilic Esophagitis in Adults Reporting Dysphagia: Development, External Validation, and Software Creation for Point-of-Care Use

Clinical Characteristics, Endoscopic Findings, and Treatment Outcomes in Lymphocytic Esophagitis Compared to Eosinophilic Esophagitis

Six-Food Elimination Diet Is Less Effective During Pollen Season in Adults With Eosinophilic Esophagitis Sensitized to Pollens

Cancer Clinical

Prehabilitation of Patients With Oesophageal Malignancy Undergoing Peri-Operative Treatment (Pre-EMPT): Outcomes From a Prospective Controlled Trial

Development of a symptom response to treatment questionnaire for patients in follow-up after oesophago-gastrectomy for cancer

REsolution of Symptoms afTer Oesophago-gastric cancer REsection delphi (RESTOREd)—standardizing the definition, investigation and management of gastrointestinal symptoms and conditions after surgery

Pathologic Lymph Node Regression After Neoadjuvant Chemotherapy Predicts Recurrence and Survival in Esophageal Adenocarcinoma: A Multicenter Study in the United Kingdom

Association of dynamic contrast-enhanced MRI and <sup>18</sup>F-Fluorodeoxyglucose PET/CT parameters with neoadjuvant therapy response and survival in esophagogastric cancer

Metabolic tumour and nodal response to neoadjuvant chemotherapy on FDG PET-CT as a predictor of pathological response and survival in patients with oesophageal adenocarcinoma

Multiple staging investigations may not change management in patients with high-grade dysplasia or early esophageal adenocarcinoma

Patient perspectives on key symptoms and preferences for follow-up after upper gastro-intestinal cancer surgery

Clinical Relevance of the Tumor Location-Modified Laurén Classification System for Gastric Cancer in a Western Population

Effect of peri-operative chemotherapy regimen on survival in the treatment of locally advanced oesophago-gastric adenocarcinoma – A comparison of the FLOT and ‘MAGIC’ regimens

Does a high Mandard score really define a poor response to chemotherapy in oesophageal adenocarcinoma?

Initial experience in staging primary oesophageal/gastro-oesophageal cancer with 18F-FDG PET/MRI

Adjuvant therapy following oesophagectomy for adenocarcinoma in patients with a positive resection margin

Machine learning to predict early recurrence after oesophageal cancer surgery

Prediction of a positive circumferential resection margin at surgery following neoadjuvant chemotherapy for adenocarcinoma of the oesophagus

Lymph node regression and survival following neoadjuvant chemotherapy in oesophageal adenocarcinoma

Inflammatory Bowel Disease

How achievable are STRIDE-II treatment targets in real-world practice and do they predict long-term treatment outcomes?

A retrospective cohort study: pre-operative oral enteral nutritional optimisation for Crohnʼs disease in a UK tertiary IBD centre

Characterization of inflammatory bowel disease with urinary metabolic profiling