Sebastian Zeki

Sebastian Zeki

Gastroenterology consultant

Guy's and St Thomas' NHS Trust

Biography

Dr Sebastian Zeki is a consultant gastroenterologist at St Thomas’ Hospital in London. His research interests include upper gastrointestinal physiology, upper gastrointestinal cancer, natural language programming and quality metrics in endoscopy. He co-leads the Gastroenterology data sciences Institute in London.

Interests

  • Endoscopic therapy
  • Oesophageal and stomach cancers/Barrett’s oesophagus
  • Oesophageal physiology
  • Heartburn; chest pain; indigestion; bloating; spasm; dyspepsia; irritable bowel syndrome; swallowing disorders; hoarse voice; chronic cough and throat clearing
  • Eosinophilic oesophagitis
  • High quality endoscopy
  • Machine learning/R/Natural language programming
  • Genomics

Education

  • PhD - Genomics of Barrett's related malignancy, 2013

    University of London

  • Member of the Royal College of Physician, 2006

  • MSc Health Informatics, 2003

    City University

  • MBBS MBChir Medicine, 2001

    University College London

  • MA in experimental psychology, 1998

    Cambridge University

Experience

 
 
 
 
 

Honorary Senior Clinical Lecturer

King’s College

Oct 2019 – Present London
Research and teaching in gastroenterology data sciences.
 
 
 
 
 

Co-head of the Gastroenterology Data Sciences Institute

Guy’s & St Thomas’ NHS Trust

Jan 2017 – Present London
Leading the Gastroenterology Data Sciences Institute.
 
 
 
 
 

Honorary Senior Clinical Lecturer

Bart’s Cancer Institute

Jan 2017 – Present London
 
 
 
 
 

Consultant Gastroenterologist

Guy’s & St Thomas’ NHS Trust

Apr 2015 – Present London
 
 
 
 
 

Clinical Lecturer

Cambridge University: MRC Hutchison

Jun 2013 – Apr 2015 London
 
 
 
 
 

PhD Student

Queen Mary University of London

Jan 2010 – Jun 2013 London
 
 
 
 
 

Gastroenterology Registrar

North West Thames Training Rotation

Jun 2006 – Jan 2016 London
 
 
 
 
 

Postgraduate Internal Medicine Training

London

Jun 2001 – Jun 2006 London

Skills

For a full overview of my clinical and academic skills, please visit my professional website at sebastianzeki.co.uk.

Visit sebastianzeki.co.uk →

Projects

EndoMineR

An R package for extracting structured data from free-text endoscopy and pathology reports, linking pathology to procedures and tracking Barrett’s surveillance timelines. View on GitHub

Gastrodatascience

An educational resource for gastroenterology data science, covering R, machine learning, and NLP applied to clinical data. Visit site

Gastroenterology Teaching Book

A free online resource for gastroenterology teaching aimed at medical students and junior doctors. Visit site

Health Foundation Grant — Improving Lesion Recognition

Using routinely collected endoscopic and pathology data to improve lesion recognition quality metrics across endoscopy units.

MiFlo

Research project exploring minimally invasive flow measurements in gastrointestinal physiology.

Physipop

Package to automate extraction of oesophageal physiology metrics https://github.com/sebastiz/Physipopv2.0.3

PhysiMiner & PhysiMinerpy

Libraries written in R and python to automate analysis of oesophageal physiology results (ph impedance, high resolution manometry and wireless pH capsules) (https://github.com/sebastiz/PhysiMineRpy & https://github.com/sebastiz/PhysiMineR)

pyEPIC & STH analytics

Python libraries for simplifying access to EPIC Clarity data and legacy data in the Enterprise Data Warehouse (EDW). (https://github.com/AgatheZ/pyEPIC & https://github.com/sebastiz/pySTH_Analytics)

EndoMiner

Zeki SS. EndoMineR for the extraction of endoscopic and associated pathology data from medical reports. Journal of Open Source Software. 2018;3(24):701. doi:10.21105/joss.00701.

Talks

IBS for General Practice — How to Approach, Help and Treat

Webinar covering evidence-based guidance for IBS diagnosis and treatment, with approaches for empowering patients.

  • Invited speaker, Royal College Physicians “Artificial intelligence in gastroenterology Vision 2020” Royal College of Physician.
  • Invited speaker, King’s Health Partners Academic Surgical Grand Round / ALRSG-BI webinar. “Intelligent physiology: a roadmap to using concurrent physiology as a surgical guide.” 25 March 2021.
  • Invited faculty/chair, London International Upper GI Symposium. Chair, Oesophageal Disorders session. 26 February 2021.
  • Invited speaker, AImed. “Automation in endoscopy.” Jan 3, 2021.
  • Invited speaker- “How to develop an Endoscopic submucosal dissection service” 2023- St Thomas’ Upper GI Day.
  • Invited speaker, Dr Falk educational meeting. Managing Complications – Eosinophilic oesophagitis Royal College of Physicians in London on Friday 22nd March 2024.
  • Invited keynote speaker, British Society of Gastroenterology Annual Meeting / BSG LIVE’25. “What is the role of Natural Language Processing in Gastroenterology?.” SEC Glasgow, 23–26 June 2025.
  • Invited speaker, British Voice Association Voice Clinics Forum. Topic: laryngopharyngeal reflux / persistent throat symptoms. Guy’s Hospital, London. 6 February 2026. “Reflux and the voice- an evidence based approach”

Funding

Research grants and awards

Can clinical decision making in Barrett’s oesophagus surveillance be automated? A study using natural language processing gastrointestinal endoscopy reports

King’s College London Sep 2021 – Sep 2024
Grant

Use of Machine Learning to automate decision making in Barrett’s oesophagus surveillance

London and South East Postgraduate Medical and Dental Education Sep 2021 – Sep 2022
Award

Improving lesion recognition using routinely collected endoscopic and pathology data

Health Foundation Oct 2019 – Feb 2021
Grant

Clonal competition and genetic evolution of Barrett’s Oesophagus

British Society of Gastroenterology Aug 2010 – Aug 2013
Grant

Endoscopy videos

Latest

Educational Role

I contribute across the KCL–GSTT academic pathway: undergraduate, postgraduate, and faculty development. Undergraduate (KCL MBBS).
Gastroenterology Small-Group Teaching Block (2016 to present), Delivering teaching bedside and through lectures ~25 students annually. Supervisor for scholarly project module 2025/6 Shan Lee “Is severe ineffective oesophageal motility at high resolution manometry related to gastro oesophageal reflux disease on impedance testing” Pierfrancesco Visaggi (June 2018 67(Suppl 1):A210.1-A210 DOI:10.1136/gutjnl-2018-BSGAbstracts.419 : “Oesophageal aperistalsis is under investigated in those without achalasia or reflux“ - oral presentation at British Society of Gastroenterology

Postgraduate:

Created innovative single subject per page online learning materials (www.gastroenteroloybook.com) with interactive multiple choice questions to improve Specialty Certificate Examination performance. Publication of MRCP book (Zeki S. The Illustrated MRCP PACES Primer. Abingdon: Radcliffe Publishing; 2009. doi:10.1201/9780429091254) to help OSCE preparation for exams Development of gastroenterology data science online teaching materials including full code examples to help manipulate large data sets using R (https://sebastiz.github.io/gastrodatascience//index.html) Endoscopy trainer Educational Supervisor Guy’s and St Thomas’ NHS Trust.

Supervision & mentoring.

Primary/secondary supervisor for 2 PhD candidates (topics: NLP for endoscopy): One PhD completion to date: Zhang X. Automating Surveillance Timing for Barrett’s Oesophagus: An Information Extraction Approach Using Natural Language Processing [Doctoral thesis]. London: King’s College London; 2026. Current primary PhD Supervisor for a second PhD : PhD supervision via the DRIVE Health programme (Agathe Zecevic “Development and deployment of a single unified natural language model for the supervised and automated prediction of follow up for precancerous GI conditions.”) (DRIVE- Health Programme)- Topol Digital Fellow

Educational innovation.

Designed an “Introduction to Clinical NLP for Gastroenterologists” workshop (hands-on notebooks using de-identified endoscopy text) now adopted by deanery study days; satisfaction 4./5. Website for NLP in gastroenterology

Training & standards.

JAG trainer and DOPS assessor; Performance optimisation done with EndoMineR. Contribution to Nocgca submission as national audit. Development of automated adenoma detection rates for colonoscopy with demonstration (Regular feedback to individual endoscopists is associated with improved adenoma detection rate and other key performance indicators for colonoscopy.Lim S, Tritto G, Zeki S, DeMartino S.Frontline Gastroenterol. 2022 May 6;13(6):509-516. doi: 10.1136/flgastro-2022-102091. eCollection 2022)

Educational RoleI contribute across the KCL–GSTT academic pathway: undergraduate, postgraduate, and faculty development.

Undergraduate (KCL MBBS).

  • Gastroenterology Small-Group Teaching Block (2016 to present),
  • Delivering teaching bedside and through lectures ~25 students annually.
  • Supervisor for scholarly project module 2025/6 Shan Lee “Is severe ineffective oesophageal motility at high resolution manometry related to gastro oesophageal reflux disease on impedance testing” Pierfrancesco Visaggi (June 2018 67(Suppl 1):A210.1-A210 DOI:10.1136/gutjnl-2018-BSGAbstracts.419 : “Oesophageal aperistalsis is under investigated in those without achalasia or reflux“ - oral presentation at British Society of Gastroenterology

Postgraduate:

  • Created innovative single subject per page online learning materials (www.gastroenteroloybook.com) with interactive multiple choice questions to improve Specialty Certificate Examination performance.
  • Publication of MRCP book (Zeki S. The Illustrated MRCP PACES Primer. Abingdon: Radcliffe Publishing; 2009. doi:10.1201/9780429091254) to help OSCE preparation for exams
  • Development of gastroenterology data science online teaching materials including full code examples to help manipulate large data sets using R (https://sebastiz.github.io/gastrodatascience//index.html)
  • Endoscopy trainer
  • Educational Supervisor Guy’s and St Thomas’ NHS Trust.

Supervision & mentoring.

  • Primary/secondary supervisor for 2 PhD candidates (topics: NLP for endoscopy):
  • One PhD completion to date: Zhang X. Automating Surveillance Timing for Barrett’s Oesophagus: An Information Extraction Approach Using Natural Language Processing [Doctoral thesis]. London: King’s College London; 2026.
  • Current primary PhD Supervisor for a second PhD : PhD supervision via the DRIVE Health programme (Agathe Zecevic “Development and deployment of a single unified natural language model for the supervised and automated prediction of follow up for precancerous GI conditions.”) (DRIVE- Health Programme)- Topol Digital Fellow

Educational innovation.

  • Designed an “Introduction to Clinical NLP for Gastroenterologists” workshop (hands-on notebooks using de-identified endoscopy text) now adopted by deanery study days; satisfaction 4./5.
  • Website for NLP in gastroenterology

Training & standards.

  • JAG trainer and DOPS assessor;
  • Performance optimisation done with EndoMineR.
  • Contribution to Nocgca submission as national audit.
  • Development of automated adenoma detection rates for colonoscopy with demonstration (Regular feedback to individual endoscopists is associated with improved adenoma detection rate and other key performance indicators for colonoscopy.Lim S, Tritto G, Zeki S, DeMartino S.Frontline Gastroenterol. 2022 May 6;13(6):509-516. doi: 10.1136/flgastro-2022-102091. eCollection 2022)

All Publications

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Precancerous niche remodelling dictates nascent tumour persistence.

G Skrupskelyte, JE Rojo Arias, H Ajith, Y Dang, D Rossetti, S Han, MKS Tang, MT Bejar, B Colom, JC Fowler, K Murai, W Knight, D Aust, MHH Schmidt, J Jászai, S Zeki, A Noorani, PH Jones, S Rulands, BD Simons, MP Alcolea
Source Document DOI

Effectiveness and safety of a haemostatic gel in the treatment of intraprocedural bleeding and prevention of delayed bleeding after advanced endoscopic resection of large and complex gastrointestinal neoplasia: a multicentre prospective observational PuraStat study

Htet, Hein Myat Thu, Subramaniam, Sharmila, Parra-Blanco, Adolfo, Saunders, Brian, Suzuki, Noriko, Haji, Amyn, Hayee, Bu’Hussain, Ang, Yeng, di Pietro, Massimiliano, Iacucci, Marietta, others

216 Feasibility of Routine Symptom Monitoring in Oesophago-Gastric Cancer Patients: Looking Toward Routine Postoperative Monitoring

Collum, Kerri-Louise, O’Brien, Catherine, Raj, Kathryn Fiona, Okten, Elif Ilayda, Taylor, Joanna, Evans, Orla, Mundle, Georgia, Zeki, Sebastian, Dunn, Jason, Baker, Cara, others

ARGENT: Automatic Reference-free Evaluation for Open-Ended Text Generation without Source Inputs

Zhang, Xinyue, Zecevic, Agathe, Zeki, Sebastian, Roberts, Angus

Development of a symptom response to treatment questionnaire for patients in follow-up after oesophago-gastrectomy for cancer

Chevallay, Mickael, Barman, Sowrav, Moss, Charlotte, Van Hemelrijck, Mieke, Evans, Orla, Taylor, Joanna, Dunn, Jason, Baker, Cara, Kelly, Mark, Knight, William, others

Impact of endoscopic pyloric dilatation on symptom relief in delayed gastric emptying after esophageal resection—use of a novel symptom response questionnaire

Chevallay, Mickael, Barman, Sowrav, Moss, Charlotte, Van Hemelrijck, Mieke, Evans, Orla, Taylor, Joanna, Dunn, Jason, Baker, Cara, Kelly, Mark, Knight, William, others

Improving Barrett’s Oesophagus Surveillance Scheduling with Large Language Models: A Structured Extraction Approach

Zhang, Xinyue, Zecevic, Agathe, Zeki, Sebastian, Roberts, Angus

Oesophageal Physiology Clinical Practice: A Case Study and Literature Review

Miah, Ismail, Wong, Terry, Zeki, Sebastian, Jafari, Jafar

P100 Clinical validation of a novel automated algorithm to detect patients eligible for hepatocellular carcinoma surveillance from clinical letters

Zecevic, Agathe, Manaois, Erycar, Wong, Terry, Wang, Bo, Zeki, Sebastian

Prehabilitation of Patients With Oesophageal Malignancy Undergoing Peri-Operative Treatment (Pre-EMPT): Outcomes From a Prospective Controlled Trial

Bott, R, Zylstra, J, Knight, W, Whyte, GP, Lane, AM, Moss, C, Browning, M, Lagergren, J, Van Hemelrijck, M, Davies, AR, others

Validating Impedance/pH Sensors for Measuring Oesophageal Transit: A Study Based on Dysphagia and Barium Swallow

Miah, Ismail, Wong, Terry, Zeki, Sebastian, Jafari, Jafar

The optimal duration of pH monitoring: testing the validity of Lyon 2.0 recommendations for wireless pH measurement

Rusu, Radu I, Fox, Mark R, Sweis, Rami, Zeki, Sebastian, Dunn, Jason M, Anggiansah, Angela, Jafari, Jafar, Learoyd, Annastazia, Wong, Terry

Automated decision making in Barrett’s oesophagus: development and deployment of a natural language processing tool

Zecevic A, Jackson L, Zhang X, Pavlidis P, Dunn J, Trudgill N, Ahmed S, Visaggi P, YoonusNizar Z, Roberts A, Zeki SS
Source Document DOI

Clinical Characteristics, Endoscopic Findings, and Treatment Outcomes in Lymphocytic Esophagitis Compared to Eosinophilic Esophagitis

Visaggi P, Savarino E, Del Corso G, Herlihy N, Ghisa M, Dunn JM, Marciano E, Wong T, Green M, de Bortoli N, Zeki S
Source Document DOI

Generation and Evaluation of Synthetic Endoscopy Free-Text Reports with Differential Privacy

Zecevic, A., Zhang, X., Zeki, S., Roberts, A.

Artificial Intelligence Tools for the Diagnosis of Eosinophilic Esophagitis in Adults Reporting Dysphagia: Development, External Validation, and Software Creation for Point-of-Care Use

Visaggi P, Del Corso G, Baiano Svizzero F, Ghisa M, Bardelli S, Venturini A, Stefani Donati D, Barberio B, Marciano E, Bellini M, Dunn J, Wong T, de Bortoli N, Savarino EV, Zeki S
Source Document DOI

REsolution of Symptoms afTer Oesophago-gastric cancer REsection delphi (RESTOREd)—standardizing the definition, investigation and management of gastrointestinal symptoms and conditions after surgery

Byrne, Ben E, Siaw-Acheampong, Kwabena, Evans, Orla, Taylor, Joanna, Huddy, Fiona, Nilsson, Magnus, Griffiths, Ewen A, Low, Donald, Gossage, James, Dunn, Jason, others

The Multichannel Intraoesophageal Impedance Transit Concept

Miah, Ismail, Wong, Terry, Zeki, Sebastian, Jafari, Jafar

Ambulatory pH-Impedance Findings Confirm That Grade B Esophagitis Provides Objective Diagnosis of Gastroesophageal Reflux Disease

Visaggi P, Del Corso G, Gyawali CP, Ghisa M, Baiano Svizzero F, Stefani Donati D, Venturini A, Savarino V, Penagini R, Zeki S, Bellini M, Savarino EV, de Bortoli N
Source Document DOI

Association of dynamic contrast-enhanced MRI and <sup>18</sup>F-Fluorodeoxyglucose PET/CT parameters with neoadjuvant therapy response and survival in esophagogastric cancer

Withey SJ, Owczarczyk K, Grzeda MT, Yip C, Deere H, Green M, Maisey N, Davies AR, Cook GJ, Goh V, Baker C, Bell J, Chang F, Chicklore S, Cominos M, Coombes A, Dunn J, George S, Gill-Barman B, Gossage J, Gourtsoyianni S, Green A, Griffin N, Hill M, Hynes O, Iezzi C, Jacques A, Kelly M, Mahadeva U, McEwan R, Meenan J, Neji R, Ngan S, Padormo F, Qureshi A, Reyhani A, Sharkey A, Spence J, Subesinghe M, Tham G, Waters J, Zeki S
Source Document DOI

Extended Wireless pH Monitoring Significantly Increases Gastroesophageal Reflux Disease Diagnoses in Patients With a Normal pH Impedance Study

Zeki SS, Miah I, Visaggi P, Wolak A, deSilva M, Dunn JM, Davies A, Gossage J, Botha A, Sui G, Jafari J, Wong T
Source Document DOI

How achievable are STRIDE-II treatment targets in real-world practice and do they predict long-term treatment outcomes?

Meade S, Routledge E, Sharma E, Honap S, Zeki S, Ray S, Anderson SHC, Sanderson J, Mawdsley J, Irving PM, Samaan MA
Source Document DOI

Joint Entity and Relation Extraction in Medical Text

Zhang, L.X., Roberts, A., Zeki, S.

Metabolic tumour and nodal response to neoadjuvant chemotherapy on FDG PET-CT as a predictor of pathological response and survival in patients with oesophageal adenocarcinoma

Moore JL, Subesinghe M, Santaolalla A, Green M, Deere H, Van Hemelrijck M, Lagergren J, Chicklore S, Maisey N, Gossage JA, Kelly M, Baker CR, Davies AR, Jacques A, Griffin N, Goh V, Ngan S, Owczarczyk K, Sita-Lumsden A, Qureshi A, Chang F, Mahadeva U, Gill-Barman B, George S, Ong M, Waters J, Cominos M, Sevitt T, Hynes O, Tham G, Dunn JM, Zeki SS
Source Document DOI

Multiple staging investigations may not change management in patients with high-grade dysplasia or early esophageal adenocarcinoma

Reyhani A, Gimson E, Baker C, Kelly M, Maisey N, Meenan J, Subesinghe M, Hill M, Lagergren J, Gossage J, Zeki S, Dunn J, Davies A
Source Document DOI

Pathologic Lymph Node Regression After Neoadjuvant Chemotherapy Predicts Recurrence and Survival in Esophageal Adenocarcinoma: A Multicenter Study in the United Kingdom

Moore JL, Green M, Santaolalla A, Deere H, Evans RP, Elshafie M, Lavery A, McManus DT, McGuigan A, Douglas R, Horne J, Walker R, Mir H, Terlizzo M, Kamarajah SK, Van Hemelrijck M, Maisey N, Sita-Lumsden A, Ngan S, Kelly M, Baker CR, Kumar S, Lagergren J, Allum WH, Gossage JA, Griffiths EA, Grabsch HI, Turkington RC, Underwood TJ, Smyth EC, Fitzgerald RC, Cunningham D, Davies AR, Puig S, Chaudry A, Jacques A, Griffin N, Goh V, Owczarczyk K, Qureshi A, Subesinghe M, Chang F, Mahadeva U, Gill-Barman B, George S, Ong M, Waters J, Cominos M, Sevitt T, Hill M, Hynes O, Tham G, Knight WRC, Dunn JM, Zeki SS
Source Document DOI

Single-centre, single-blinded, randomised, parallel group, feasibility study protocol investigating if mandibular advancement device treatment for obstructive sleep apnoea can reduce nocturnal gastro-oesophageal reflux (MAD-Reflux trial)

O'Toole S, Moazzez R, Wojewodka G, Zeki S, Jafari J, Hope K, Brand A, Hoare Z, Scott S, Doungsong K, Ezeofor V, Edwards RT, Drakatos P, Steier J
Source Document DOI

Six-Food Elimination Diet Is Less Effective During Pollen Season in Adults With Eosinophilic Esophagitis Sensitized to Pollens

Visaggi P, Savarino E, Del Corso G, Hunter H, Baiano Svizzero F, Till SJ, Dunn J, Wong T, de Bortoli N, Zeki S
Source Document DOI

The Illustrated MRCP PACES Primer

Zeki S
Source Document DOI

Transnasal endoscopy: Moving from endoscopy to the clinical outpatient-blue sky thinking in oesophageal testing

Lim S, Haboubi HN, Anderson SHC, Dawson P, Machado AP, Mangsat E, Santos S, Wong T, Zeki S, Dunn J
Source Document DOI

Clinical Relevance of the Tumor Location-Modified Laurén Classification System for Gastric Cancer in a Western Population

Moore JL, Davies AR, Santaolalla A, Van Hemelrijck M, Maisey N, Lagergren J, Gossage JA, Kelly M, Baker CR, Jacques A, Griffin N, Goh V, Ngan S, Lumsden A, Owczarczyk K, Qureshi A, Deere H, Green M, Chang F, Mahadeva U, Gill-Barman B, George S, Meenan J, Hill M, Waters J, Cominos M, Hynes O, Tham G, Bott RK, Dunn JM, Zeki SS
Source Document DOI

Effect of peri-operative chemotherapy regimen on survival in the treatment of locally advanced oesophago-gastric adenocarcinoma – A comparison of the FLOT and ‘MAGIC’ regimens

Moore JL, Kumar S, Santaolalla A, Patel PH, Kapiris M, Van Hemelrijck M, Maisey N, Hill M, Lagergren J, Gossage JA, Kelly M, Chaudry A, Allum WH, Baker CR, Cunningham D, Davies AR, Jacques A, Griffin N, Goh V, Ngan S, Owczarczyk K, Lumsden A, Qureshi A, Deere H, Green M, Chang F, Mahadeva U, Gill-Barman B, George S, Ong M, Waters J, Cominos M, Sevitt T, Hynes O, Tham G, Bott R, Dunn J, Zeki S
Source Document DOI

Low-cost and clinically applicable copy number profiling using repeat DNA

Abujudeh S, Zeki SS, van Lanschot MC, Pusung M, Weaver JM, Li X, Noorani A, Metz AJ, Bornschein J, Bower L, Miremadi A, Fitzgerald RC, Morrissey ER, Lynch AG
Source Document DOI

Patient perspectives on key symptoms and preferences for follow-up after upper gastro-intestinal cancer surgery

Pucher PH, Coombes A, Evans O, Taylor J, Moore JL, White A, Lagergren J, Baker C, Kelly M, Gossage JA, Dunn J, Zeki S, Byrne BE, Andreyev J, Davies AR
Source Document DOI

A retrospective cohort study: pre-operative oral enteral nutritional optimisation for Crohnʼs disease in a UK tertiary IBD centre

Meade S, Patel KV, Luber RP, O'Hanlon D, Caracostea A, Pavlidis P, Honap S, Anandarajah C, Griffin N, Zeki S, Ray S, Mawdsley J, Samaan MA, Anderson SH, Darakhshan A, Adams K, Williams A, Sanderson JD, Lomer M, Irving PM
Source Document DOI

Regular feedback to individual endoscopists is associated with improved adenoma detection rate and other key performance indicators for colonoscopy

Lim S, Tritto G, Zeki S, DeMartino S
Source Document DOI

Transition from esophagectomy to endoscopic therapy for early esophageal cancer

Dunn JM, Reyhani A, Santaolalla A, Zylstra J, Gimson E, Pennington M, Baker C, Kelly M, Van Hemelrijck M, Lagergren J, Zeki SS, Gossage JA, Davies AR
Source Document DOI

Positioning intestinal ultrasound in a UK tertiary centre: Significant estimated clinical role and cost savings

Luber RP, Petri B, Meade S, Honap S, Zeki S, Gecse KB, Griffin N, Irving PM
Source Document DOI

Validation of the Lyon classification for GORD diagnosis: Acid exposure time assessed by prolonged wireless pH monitoring in healthy controls and patients with erosive oesophagitis

Rusu R, Fox MR, Tucker E, Zeki S, Dunn JM, Jafari J, Warburton F, Wong T
Source Document DOI

Initial experience in staging primary oesophageal/gastro-oesophageal cancer with 18F-FDG PET/MRI

Sharkey AR, Sah B, Withey SJ, Bhuva S, Neji R, Jeljeli S, Green A, Cook GJR, Goh V, Baker CR, Chang F, Chicklore S, Cominos M, Coombes A, Davies AR, George S, Gill-Barman B, Dunn JN, Gossage JA, Griffin N, Hill M, Hynes O, Iezzi C, Jacques A, Kelly M, Mahadeva U, Maisey N, McEwan R, Meenan J, Ngan S, Owczarczyk K, Qureshi A, Reyhani A, Subesinghe M, Tham G, Waters J, Zeki SS
Source Document DOI

O32 Defining normal ranges for 96-hour wireless PH monitoring using healthy controls

Sebastian Zeki

OFR-3 Extended wireless pH monitoring increases GERD diagnoses in patients with a normal pH impedance study

Sebastian Zeki

P-OGC21 Patient perspectives on symptoms of importance and preferences for follow-up after major upper gastro-intestinal cancer surgery

Sebastian Zeki

P126 Phenotypic characterisation of suspected small bowel Crohn�s disease with natural language processing of MRE reports

Sebastian Zeki

P229 A novel approach to radiotherapy targeting for oesophageal squamous-cell cancer using lugol�s-solution guided endoclip marking

Sebastian Zeki

P230 Prevalence of cervical inlet patch in patients with and without globus

Sebastian Zeki

P231 An evaluation of the endoscopic, pathologic and radiologic features of 225 patients with eosinophilic oesophagitis

Sebastian Zeki

P237 Accuracy of the PPI test for reflux disease diagnosis: comparison with wireless ph study data

Sebastian Zeki

P44 Regular individual feedback on key performance indicators improves polyp and adenoma detection in colonoscopy

Sebastian Zeki

PMO-26 Intestinal ultrasound instead of endoscopy: large potential role and cost savings

Sebastian Zeki

PTH-35 Out-of-hours dedicated trans-nasal endoscopy service--a model for endoscopy recovery during COVID pandemic

Sebastian Zeki

PTH-67 Low rate of post-fundoplication dysphagia in patients with pre-operative oesophageal aperistalsis

Sebastian Zeki

PTH-68 Schatzki rings are commonly misdiagnosed in patients with eosinophilic oesophagitis

Sebastian Zeki

PTH-69 Short segment non dysplastic Barrett’s is often surveyed too early by non-experts

Sebastian Zeki

PTH-76 Use of orodispersible budesonide in the treatment of eosinophilic oesophagitis: a single-centre audit

Sebastian Zeki

PTU-4 Prospective validation of the edinburgh dysphagia score in South-east London

Sebastian Zeki

Does a high Mandard score really define a poor response to chemotherapy in oesophageal adenocarcinoma?

Knight WRC, Baker CR, Griffin N, Wulaningsih W, Kelly M, Davies AR, Gossage JA, Hynes O, Tham G, Iezzi C, Bott R, Maisey N, Gaya A, Ngan S, Qureshi A, Green M, Jacques A, Goh V, Deere H, Chang F, Mahadeva U, Gill-Barman B, George S, Dunn J, Zeki S, Meenan J
Source Document DOI

Adjuvant therapy following oesophagectomy for adenocarcinoma in patients with a positive resection margin

Bott, R.K., Beckmann, K., Zylstra, J., Wilkinson, M.J., Knight, W.R.C., Baker, C.R., Kelly, M., Maisey, N., Qureshi, A., Sevitt, T., Van Hemelrijck, M., Smyth, E.C., Allum, W.H., Lagergren, J., Gossage, J.A., Cunningham, D., Davies, A.R., McEwan, R., Jacques, A., Griffin, N., Goh, V., Ngan, S., Owczarczyk, K., Deere, H., Green, M., Chang, F., Mahadeva, U., Gill-Barman, B., George, S., Meenan, J., Hill, M., Waters, J., Cominos, M., Hynes, O., Coombes, A., Tham, G., Iezzi, C., Reyhani, A., Dunn, J.M., Zeki, S.S.
Source Document DOI

Machine learning to predict early recurrence after oesophageal cancer surgery

Rahman SA, Walker RC, Lloyd MA, Grace BL, van Boxel GI, Kingma BF, Ruurda JP, van Hillegersberg R, Harris S, Parsons S, Mercer S, Griffiths EA, O'Neill JR, Turkington R, Fitzgerald RC, Underwood TJ, Noorani A, Elliott RF, Edwards PAW, Grehan N, Nutzinger B, Crawte J, Chettouh H, Contino G, Li X, Gregson E, Zeki S, de la Rue R, Malhotra S, Tavaré S, Lynch AG, Smith ML, Davies J, Crichton C, Carroll N, Safranek P, Hindmarsh A, Sujendran V, Hayes SJ, Ang Y, Preston SR, Oakes S, Bagwan I, Save V, Skipworth RJE, Hupp TR, O'Neill JR, Tucker O, Beggs A, Taniere P, Puig S, Underwood TJ, Noble F, Byrne JP, Kelly JJ, Owsley J, Barr H, Shepherd N, Old O, Lagergren J, Gossage J, Chang ADF, Zylstra J, Goh V, Ciccarelli FD, Sanders G, Berrisford R, Harden C, Bunting D, Lewis M, Cheong E, Kumar B, Parsons SL, Soomro I, Kaye P, Saunders J, Lovat L, Haidry R, Eneh V, Igali L, Scott M, Sothi S, Suortamo S, Lishman S, Hanna GB, Peters CJ, Grabowska A
Source Document DOI

The effects of COVID-19 on IBD prescribing and service provision in a UK tertiary centre

Sebastian Zeki

Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction.

Cancers occurring at the gastroesophageal junction (GEJ) are classified as predominantly esophageal or gastric, which is often …
Bornschein J, Wernisch L, Secrier M, Miremadi A, Perner J, MacRae S, O'Donovan M, Newton R, Menon S, Bower L, Eldridge MD, Devonshire G, Cheah C, Turkington R, Hardwick RH, Selgrad M, Venerito M, Malfertheiner P, Fitzgerald R, Noorani A, Elliott RF, Edwards PAW, Grehan N, Nutzinger B, Crawte J, Chettouh H, Contino G, Li X, Gregson E, Zeki S, de la Rue R, Malhotra S, Tavaré S, Lynch AG, Smith ML, Davies J, Crichton C, Carroll N, Safranek P, Hindmarsh A, Sujendran V, Hayes SJ, Ang Y, Preston SR, Oakes S, Bagwan I, Save V, Skipworth RJE, Hupp TR, Robert O'Neill J, Tucker O, Beggs A, Taniere P, Puig S, Underwood TJ, Noble F, Owsley J, Barr H, Shepherd N, Old O, Lagergren J, Gossage J, Davies A, Chang F, Zylstra J, Goh V, Ciccarelli FD, Sanders G, Berrisford R, Harden C, Bunting D, Lewis M, Cheong E, Kumar B, Parsons SL, Soomro I, Kaye P, Saunders J, Lovat L, Haidry R, Eneh V, Igali L, Scott M, Sothi S, Suortamo S, Lishman S, Hanna GB, Peters CJ, Grabowska A
DOI

Su1136--Can Peroral Endoscopic Myotomy (POEM) Become the Treatment of Choice for Achalasia? Results of a Singlecenter Institute in UK

Sebastian Zeki

Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction

Sebastian Zeki

OTH-07 Identification of IBD cohorts from linked endoscopy and histology reports using natural language processing

Sebastian Zeki

P27 PERORAL ENDOSCOPIC MYOTOMY (POEM) FOR TREATMENT OF ACHALASIA. CLINICAL OUTCOMES OF A SINGLE-CENTER INSTITUTE IN UK

Sebastian Zeki

Prediction of a positive circumferential resection margin at surgery following neoadjuvant chemotherapy for adenocarcinoma of the oesophagus

Knight WRC, Yip C, Wulaningsih W, Jacques A, Griffin N, Zylstra J, Van Hemelrijck M, Maisey N, Gaya A, Baker CR, Kelly M, Gossage JA, Lagergren J, Landau D, Goh V, Davies AR, Ngan S, Qureshi A, Deere H, Green M, Chang F, Mahadeva U, Gill‐Barman B, George S, Dunn J, Zeki S, Meenan J, Hynes O, Tham G, Iezzi C
Source Document DOI

PTU-047 POEM compares favorably with laparoscopic hellers myotomy as treatment for achalasia

Sebastian Zeki

PTU-105 Automated, algorithm based extraction of Barrett�s surveillance metrics from natural language text is reliable

Sebastian Zeki

O26 QUALITY OF LIFE FOR ACHALASIA PATIENTS IS THE SAME AFTER PER-ORAL ENDOSCOPIC MYOTOMY (POEM) AND HELLER MYOTOMY

Sebastian Zeki

A biomarker panel predicts progression of Barrett's esophagus to esophageal adenocarcinoma

Duits LC, Lao-Sirieix P, Wolf WA, O’Donovan M, Galeano-Dalmau N, Meijer SL, Offerhaus GJA, Redman J, Crawte J, Zeki S, Pouw RE, Chak A, Shaheen NJ, Bergman JJGHM, Fitzgerald RC
Source Document DOI

Field cancerization in Barrett's esophagus.

Barrett’s esophagus is a columnar metaplasia conferring an increased risk of adenocarcinoma development. Evidence suggests that …
Zeki SS, Graham TA, Wright NA
Source Document

The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands

POBJECTIVE: Barrett’s oesophagus shows appearances described as ‘intestinal metaplasia’, in structures called …
Lavery DL, Nicholson AM, Poulsom R, Jeffery R, Hussain A, Gay LJ, Jankowski JA, Zeki SS, Barr H, Harrison R
DOI

The use of molecular markers in predicting dysplasia and guiding treatment.

The ability to stratify patients based on the risk of progression to oesophageal adenocarcinoma would provide benefit to patients as …
Zeki S, Fitzgerald RC.
DOI

Multidisciplinary approach to the management of adult eosinophilic oesophagitis in the United Kingdom

Dietary intervention is effective for the management of eosinophilic oesophagitis (EoE) in both adults and children. The majority of research has been conducted in Spain or the United States, with no studies of dietary intervention published in the United Kingdom. Restrictive elimination diets can be challenging…….
Hannah Hunter, Kristina Pupinyte, Terry Wong, Sebastian Zeki, Jason M. Dunn, Evelyn Toner, Stephen J. Till, Miranda C. E. Lomer
DOI

EndoMineR for the extraction of endoscopic and associated pathology data from medical reports

Medical data is increasingly kept in an electronic format worldwide (Bretthauer M. 2016).This serves many purposes including more efficient storage, distribution and accessibility of patient-focussed data. As important is the ability to analyse healthcare data for to optimize resource deployment and usage……
Sebastian Zeki
DOI

EndoMineR for the extraction of endoscopic and associated pathology data from medical reports

S Zeki S
Source Document DOI

Impact of incremental circumferential resection margin distance on overall survival and recurrence in oesophageal adenocarcinoma

BACKGROUND:Previous analyses of the oesophageal circumferential resection margin (CRM) have focused on the prognostic validity of two …
Knight, W. R., Zylstra, J., Wulaningsih, W. , Van Hemelrijck, M., Landau, D., Maisey, N., Gaya, A., Baker, C. R., Gossage, J. A., Largergren, J., Davies, A. R., Kelly, M., Hynes, O., Tham, G., Iezzi, C., Cowie, A., Ngan, S., Qureshi, A., Green, M., Griffin, N., Jacques, A., Goh, V., Deere, H., Chang, F., Mahadeva, U., Gill‐Barman, B., George, S., Dunn, J., Zeki, S., Meenan, J
DOI

Tu1124-Risk Factors for Bleeding During Endoscopic Resection for Visible Lesions in Barrett's Esophagus

Sebastian Zeki

Endoscopic management of dysplasia and early oesophageal cancer

Zeki S, Bergman J, Dunn J
Source Document DOI

Lymph node regression and survival following neoadjuvant chemotherapy in oesophageal adenocarcinoma

Davies AR, Myoteri D, Zylstra J, Baker CR, Wulaningsih W, Van Hemelrijck M, Maisey N, Allum WH, Smyth E, Gossage JA, Lagergren J, Cunningham D, Green M, Kelly M, Ngan S, Qureshi A, Gaya A, Griffin N, Jacques A, Goh V, Deere H, Chang F, Mahadeva U, Gill-Barman B, George S, Dunn J, Zeki S, Meenan J, Hynes O, Tham G, Iezzi C, Dellaportas D, Cowie A, Knight W, Valeri N
Source Document DOI

Multidisciplinary approach to the management of adult eosinophilic oesophagitis in the United Kingdom

Hunter H, Pupinyte K, Wong T, Zeki S, Dunn JM, Toner E, Till SJ, Lomer MCE
Source Document DOI

OTU-013 Outcomes of 360 HALO express radio-frequency ablation for barrett�s oesophagus related neoplasia

Sebastian Zeki

OWE-031 Oesophageal aperistalsis is under investigated in those without achalasia or reflux

Sebastian Zeki

Clonal Diaspora in Metastatic Esophageal Adenocarcinoma Describes a New Model of Cancer Progression

Noorani A, Goddard M, Crawte J, Alexandrov LB, Secrier M, Eldridge MD, Bower L, Li X, Weaver J, LaooSirieix P, Martincorena I, DebirammBeecham I, Grehan N, MacRae S, Malhotra S, Miremadi A, Thomas T, Galbraith S, Petersen L, Preston SD, Gilligan D, Hindmarsh A, Hardwick RH, Consortium O, Stratton MR, Wedge DC, Fitzgerald RC
Source Document DOI

PTH-128 Bravo wireless PH monitoring can save time when investigating patients with eosinophilic oesophagitis

Sebastian Zeki

PTU-144 Removal of normal and negative phrases from endoscopic semi-structured text for accurate automated endoscopic audit

Sebastian Zeki

PTH-024 Risk factors for bleeding during endoscopic resection for visible lesions in barrett�s oeosphagus

Sebastian Zeki

A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre- and post-chemotherapy.

Cancers occurring at the gastroesophageal junction (GEJ) are classified as predominantly esophageal or gastric, which is often …
Noorani A, Bornschein J, Lynch AG, Secrier M, Achilleos A, Eldridge M, Bower L, Weaver JMJ, Crawte J, Ong CA, Shannon N, MacRae S, Grehan N, Nutzinger B, O'Donovan M, Hardwick R, Tavaré S, Fitzgerald RC, Elliott RF, Edwards PAW, Li X, Chettouh H, Contino G, Gregson E, Zeki S, Smith L, Abdullahi Z, de la Rue R, Miremadi A, Malhotra S, Smith ML, Davies J, Crichton C, Carroll N, Safranek P, Hindmarsh A, Sujendran V, Turkington R, Hayes SJ, Ang Y, Preston SR, Oakes S, Bagwan I, Save V, Skipworth RJE, Hupp TR, O'Neill JR, Tucker O, Beggs A, Taniere P, Puig S, Underwood TJ, Noble F, Owsley J, Barr H, Shepherd N, Old O, Lagergren J, Gossage J, Davies A, Chang F, Zylstra J, Sanders G, Berrisford R, Harden C, Bunting D, Lewis M, Cheong E, Kumar B, Parsons SL, Saunders J, Soomro I, Kaye P, Lovat L, Haidry R, Eneh V, Igali L, Welch IM, Scott M, Sothi S, Suortamo S, Lishman S, Grabowska A, Peters CJ, Hanna GB, Khoo D, Beardsmore D
DOI

A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre-and post-chemotherapy

Sebastian Zeki

Experienced endoscopists improve Barrett's surveillance outcomes independently of time allocation Reply

Sebastian Zeki

Reply to Westerveld et aland Schembri et al.

Zeki S, Ooi J, Wilson P, Walker G, Blaker P, DeMartino S, O’Donohue J, Reffitt D, Lanaspre E, Chang F, Meenan J, Dunn J
Source Document DOI

Uvular necrosis following diagnostic gastroscopy

Digby-Bell J, Zeki S
Source Document DOI

Genomics of esophageal cancer and biomarkers for early detection

Pusung M, Zeki S, Fitzgerald R
Source Document DOI

A biomarker panel predicts progression of Barrett's esophagus to esophageal adenocarcinoma

Progression from Barrett’s esophagus (BE) to esophageal adenocarcinoma (EAC) is uncommon but the consequences are serious. …
L C Duits, P Lao-Sirieix, W A Wolf, M O’Donovan, N Galeano-Dalmau, S L Meijer, G J A Offerhaus, J Redman, J Crawte, S Zeki, R E Pouw, A Chak, N J Shaheen, J J G H M Bergman, R C Fitzgerald
DOI

54 evaluation of a minimally-invasive cytosponge esophageal cell collection system in patients with Barrett's esophagus

Sebastian Zeki

The use of molecular markers in predicting dysplasia and guiding treatment

Zeki S, Fitzgerald RC
Source Document DOI

Targeting care in Barrett's oesophagus

Barretts oesophagus represents the most significant risk factor for the development of oesophageal adenocarcinoma (OAC), although the majority of patients will not develop cancer. However, early detection of OAC……
Zeki S, Fitzgerald RC.
DOI

Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis

Cancer genome sequencing studies have identified numerous driver genes, but the relative timing of mutations in carcinogenesis remains …
Weaver JMJ, Ross-Innes CS, Shannon N, Lynch AG, Forshew T, Barbera M, Murtaza M, Ong CJ, Lao-Sirieix P, Dunning MJ, Smith L, Smith ML, Anderson CL, Carvalho B, O'Donovan M, Underwood TJ, May AP, Grehan N, Hardwick R, Davies J, Oloumi A, Aparicio S, Caldas C, Eldridge MD, Edwards PAW, Rosenfeld N, Tavaré S, Fitzgerald RC, OCCAMS consortium
DOI

Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis

Weaver JMJ, Ross-Innes CS, Shannon N, Lynch AG, Forshew T, Barbera M, Murtaza M, Ong CJ, Lao-Sirieix P, Dunning MJ, Smith L, Smith ML, Anderson CL, Carvalho B, O'Donovan M, Underwood TJ, May AP, Grehan N, Hardwick R, Davies J, Oloumi A, Aparicio S, Caldas C, Eldridge MD, Edwards PAW, Rosenfeld N, Tavaré S, Fitzgerald RC
Source Document DOI

Squamous cell carcinoma after radiofrequency ablation for Barrett's dysplasia

Zeki SS
Source Document DOI

Targeting care in Barrett's oesophagus

Zeki S, Fitzgerald RC
Source Document DOI

The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands

Lavery DL, Nicholson AM, Poulsom R, Jeffery R, Hussain A, Gay LJ, Jankowski JA, Zeki SS, Barr H, Harrison R, Going J, Kadirkamanathan S, Davis P, Underwood T, Novelli MR, Rodriguez–Justo M, Shepherd N, Jansen M, Wright NA, McDonald SAC
Source Document DOI

Clonal Selection and Persistence in Dysplastic Barrett's Esophagus and Intramucosal Cancers After Failed Radiofrequency Ablation

Radiofrequency ablation (RFA) is used to successfully eliminate Barrett’s esophagus (BE)-related dysplasia or intramucosal carcinoma and aims to cause reversion to squamous epithelium. However, in 20% of cases RFA fails to return……
Sebastian S Zeki, Rehan Haidry, Trevor A Graham, Manuel Rodriguez-Justo, Marco Novelli, Jonathon Hoare, Jason Dunn, Nicholas A Wright, Laurence B Lovat, Stuart AC McDonald
DOI

Clonal Interactions in Barrett�s Carcinogenesis.

Sebastian Zeki

Clonal selection and persistence in dysplastic Barrett's esophagus and intramucosal cancers after failed radiofrequency ablation

Zeki SS, Haidry R, Graham TA, Rodriguez-Justo M, Novelli M, Hoare J, Dunn J, Wright NA, Lovat LB, McDonald SA
Source Document DOI

Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells

Khan S, McDonald SA, Wright NA, Graham TA, Odze RD, Rodriguez‐Justo M, Zeki S
Source Document DOI

Mo1859 Senescent Barrett's Epithelium Causes Proliferation of Neighbouring Non Senescent Epithelium by Paracrine Signalling

Sebastian Zeki

Mo1623 Barretts Related Adenocarcinomas Arise as a Monoclonal Outgrowth From Polyclonal Dysplasia

Sebastian Zeki

Reply - Refeeding hypophosphataemia in patients with malnutrition: Prevention and treatment

Zeki S, Nightingale JM
Source Document DOI

Utilizing DNA mutations to trace epithelial cell lineages in human tissues

Zeki S, Graham TA, McDonald SAC
Source Document DOI

Tu1116 Recurrence After Radiofrequency Ablation for Barretts Related High Grade Dysplasia is Due to Persistence of Epithelial Mutations

Sebastian Zeki

Stem cells and their implications for colorectal cancer

The colonic crypt is home to several multipotent stem cells. These stem cells reside in a niche at the base of the crypt, which …
Sebastian Zeki, Trevor A Graham, Nicholas A Wright
DOI

Field cancerization in Barrett's esophagus.

Zeki, S.S., McDonald, S.A., Graham, T.A.

Refeeding hypophosphataemia is more common in enteral than parenteral feeding in adult in patients

Zeki S, Culkin A, Gabe SM, Nightingale JM
Source Document DOI

Stem cells and their implications for colorectal cancer

Zeki SS, Graham TA, Wright NA
Source Document DOI

A deceptive magnetic resonance cholangiopancreatogram?

Sebastian Zeki

T1322 Colectomy Rates for Patients Treated for CMV Disease in the Context of Ulcerative Colitis do Not Differ From Those Who are Not Treated for CMV Disease

Sebastian Zeki

An obstructing mass in a young ulcerative colitis patient

Zeki S, Catnach S, King A, Hallan R
Source Document DOI

Characterization of inflammatory bowel disease with urinary metabolic profiling

Williams HRT, Cox IJ, Walker DG, North BV, Patel VM, Marshall SE, Jewell DP, Ghosh S, Thomas HJW, Teare JP, Jakobovits S, Zeki S, Welsh KI, Taylor-Robinson SD, Orchard TR
Source Document DOI

Erratum: Characterization of inflammatory bowel disease with urinary metabolic profiling (American Journal of Gastroenterology (2009) 104 (1435-1444) DOI: 10.1038 / ajg.2009.175)

Williams HRT, Cox IJ, Walker DG, North BV, Patel VM, Marshall SE, Jewell DP, Ghosh S, Thomas HJ, Teare JP, Jakobovits S, Zeki S, Welsh KI, Taylor-Robinson SD, Orchard TR
Source Document DOI

Risk factors for severe disease in adults with falciparum malaria

Phillips A, Bassett P, Zeki S, Newman S, Pasvol G
Source Document DOI

S1180 Crohn's Disease Is Associated with a Specific Urinary Metabolic Profile

Sebastian Zeki
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